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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6893 | MK-886 | MK886,L 663536 | Apoptosis , Leukotriene Receptor , COX , PPAR , FLAP |
MK-886 (L 663536) is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist. | |||
T7786 | Tryptanthrin | DNA gyrase | |
Tryptanthrin is a natural DNA gyrase inhibitor. | |||
T24327 | L 674573 | L 674,573,L674,573,L-674,573,L674573,L-674573 | Leukotriene Receptor |
L 674573 is an inhibitor of leukotriene biosynthesis. | |||
T77638 | BIRM 271 | Phospholipase , LTR | |
BIRM 271 is a novel arachidonic acid release inhibitor that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. BIRM 271 and BIRM 270 are enantiomers that inhibit the production of leu... | |||
T16087 | Quiflapon | MK-591 | Apoptosis , FLAP |
Quiflapon (MK-591) causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) and is also an effective and orally active Leukotr... | |||
T24322 | L 669083 | L669,083,L-669,083,L 669,083,L-669083,L669083 | |
L 669083 is two classes of potent leukotriene biosynthesis inhibitors photoaffinity analogue. | |||
T24340 | L 691678 | L-691678,L691678 | |
L 691678 is a potent leukotriene biosynthesis inhibitor. | |||
T24337 | L 689037 | L-689037,L689037,L689,037,L 689,037,L-689,037 | |
L 689037 is an inhibitor of leukotriene biosynthesis. | |||
T71309 | MK-886 sodium salt | ||
MK-886 sodium salt inhibits leukotriene biosynthesis in leukocytes. | |||
T68314 | DG-051 | ||
DG-051 is a novel leukotriene A4 (LTA4H) hydrolase inhibitor of leukotriene B4 biosynthesis. | |||
T69385 | Baicalein monohydrate | ||
Baicalein monohydrate is an inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. | |||
T73793 | 20-Carboxy-Leukotriene B4 | ||
20-Carboxy-Leukotriene B4 (20-COOH LTB4), a metabolite of Leukotriene B4 (LTB4), exhibits high affinity binding to the BLT1 receptor. It notably inhibits LTB4-mediated neutrophil responses, including migration, degranula... | |||
TN6057 | 1-Methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone | (Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one | |
(Z)-1-Methyl-2-(undec-6-enyl)quinolin-4(1H)-one shows strong inhibitory activity on leukotriene biosynthesis in human polymorphonuclear granulocytes, and it is very effective against mycobacteria. | |||
TN2552 | 1-Methyl-2-nonylquinolin-4(1H)-one | Others | |
1-Methyl-2-nonylquinolin-4(1H)-one has anti-inflammatory activity, it exhibits inhibitory activity on leukotriene biosynthesis in a bioassay using human polymorphonuclear granulocytes, with IC50 values of 12.1 microM. | |||
TN5070 | Stilbostemin B | Others | |
Stilbostemin A, stilbostemin B , stilbostemin D , stilbostemin F , and stilbostemin G show structure-dependent inhibition of leukotriene biosynthesis with IC(50) values ranging from 3.7 to >50 microM. | |||
T27026 | CJ-13,610 | CJ 13610,CJ-13610 | Lipoxygenase |
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. |